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Tropisetron

CAT: 0013-GTR19217002-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19217002-01Size:1 g
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Description
Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively. (In Vitro) :The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB. (In Vivo) :Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.
CAS Number
89565-68-4
Product Name Alternative
ICS 205-930 | Tropisetronum | Tropisteron
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Smiles
CN1C2CCC1CC (C2) OC (=O) c1c[nH]c2ccccc12
Molecular Formula
C17H20N2O2
Molecular Weight
284.359
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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