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BiP inducer X

CAT: 0013-GTR19216558-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216558-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP) /GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines. (In Vitro) :Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway. (In Vivo) :In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction.
CAS Number
101714-41-4
Product Name Alternative
BIX
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (238.98 mM)
Smiles
Oc1ccc (cc1O) C (=O) CSC#N
Molecular Formula
C9H7NO3S
Molecular Weight
209.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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