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Ajmalicine

CAT: 0013-GTR19216448-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216448-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。 (In Vitro) :Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2. (In Vivo) :Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline.
CAS Number
483-04-5
Product Name Alternative
Raubasine | Delta-Yohimbine | Ajmalicin | Lamuran
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 5.56 mg/mL (15.78 mM)
Smiles
[H][C@@]12C[C@]3 ([H]) C (=CO[C@@H] (C) [C@@]3 ([H]) CN1CCc1c2[nH]c2ccccc12) C (=O) OC
Molecular Formula
C21H24N2O3
Molecular Weight
352.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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