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DSRM-3716

CAT: 0013-GTR19216444-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216444-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1 (IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons. (In Vitro) :Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner.
CAS Number
58142-99-7
Product Name Alternative
5-Iodoisoquinoline
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (196.03 mM)
Smiles
Ic1cccc2cnccc12
Molecular Formula
C9H6IN
Molecular Weight
255.06
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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