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α-Humulene

CAT: 0013-GTR19216303-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216303-01Size:200 mg
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Description
α-Humulene is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression. (In Vitro) :The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC (50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene (Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC (50) values of 90.5 and 145.8 mu g/ml. The cytotoxicity of α-Humulene against human lung carcinoma A549, colon adenocarcinoma DLD-1, skin fibroblasts WS1 cell lines is 28±1, 43±3, and 24±3 μg/mL, respetctively.
CAS Number
6753-98-6
Product Name Alternative
Humulene | α-Caryophyllene
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 33.33 mg/mL (163.10 mM)
Smiles
C\C1=C/CC (C) (C) \C=C\C\C (C) =C\CC1
Molecular Formula
C15H24
Molecular Weight
204.357
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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