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Propargyl-PEG4-acid

CAT: 0013-GTR19215722-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19215722-01Size:100 mg
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Description
Propargyl-PEG4-acid is a polyethylene glycol (PEG) linker utilized in constructing PROTAC molecules, such as BTK-targeting degraders derived from Ibrutinib. For instance, a related PROTAC 3 degrades Bruton's Tyrosine Kinase (BTK) with a DC50 of 200 nM in THP-1 cell-based assays, demonstrating its application in targeted protein degradation research.
CAS Number
1415800-32-6
Field of Research
Pharmacology & Drug Discovery
Smiles
C (OCCOCCOCC#C) COCCC (O) =O
Molecular Formula
C12H20O6
Molecular Weight
260.28
Storage Conditions
-20°C
Notes
For research use only.

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