IXA4

• Description :

  IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response) . IXA4 reduces secretion of APP through IRE1 activation[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  IRE1

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ixa4.html

• Purity :

  98.83

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N(C)CCOC1=CC=C(C)C=C1)CN2N=CC(NC(CCOC3=CC=CC=C3)=O)=C2

• Molecular Formula :

  C24H28N4O4

• Molecular Weight :

  436.50

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Grandjean JMD, et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nat Chem Biol. 2020;16 (10) :1052-1061.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1185329-96-7]