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Naluzotan hydrochloride

CAT: 0013-GTR19213663-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213663-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Naluzotan hydrochloride (PRX 00023 hydrochloride) is a potent and selective 5-HT1A receptor agonist (Ki ~5.1 nM) and a hERG K+ channel blocker (IC50 3800 nM) . It is a research compound used in preclinical studies investigating anxiety and depression, including in vitro receptor binding assays and in vivo behavioral models.
CAS Number
740873-82-9
Product Name Alternative
5HT Receptor, 5HTReceptor, 5-HT1A, Naluzotan Hydrochloride, hERG Potassium Channel, PRX00023 Hydrochloride, PRX-00023 Hydrochloride, PRX 00023 hydrochloride, PRX 00023 Hydrochloride
Field of Research
Cardiovascular Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.61% (May vary between batches)
Solubility
DMSO:50 mg/mL (102.65 mM)
Smiles
Cl.O=C (NC1=CC=CC (=C1) N2CCN (CC2) CCCCNS (=O) (=O) CC3CCCCC3) C
Molecular Formula
C23H39ClN4O3S
Molecular Weight
487.1
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Naluzotan Hydrochloride

See also: Naluzotan (has active moiety).

CAS Number740873-82-9
PubChem CID25096194
IUPAC NameN-[3-[4-[4-(cyclohexylmethylsulfonylamino)butyl]piperazin-1-yl]phenyl]acetamide;hydrochloride
Molecular FormulaC23H39ClN4O3S
Molecular Weight487.1
Topological Polar Surface Area90.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Heavy Atom Count32
Formal Charge0
Complexity638
SMILES
CC(=O)NC1=CC(=CC=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3.Cl
InChI
InChI=1S/C23H38N4O3S.ClH/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21;/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28);1H
InChIKey
QBACIVGQRFVOBZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Naluzotan Hydrochloride
CAS: 740873-82-9
CID: 25096194
Formula: C23H39ClN4O3S
MW: 487.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight487.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass486.2431400
Monoisotopic Mass486.2431400
Topological Polar Surface Area90.1 Ų
Heavy Atom Count32
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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