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GPS167

CAT: 0013-GTR19213214Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213214Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.GPS167 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.GPS167 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.GPS167 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.GPS167 is cytotoxic for human colorectal cancer organoids but not normal organoids.
Purity
>97%
Smiles
O=C (C1=CSC (NC2=CC=CC=C2) =N1) NC3=CC4=C (NN=C4) C=C3
Molecular Formula
C17H13N5OS
Molecular Weight
335.385
Notes
For research use only.

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