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DW0254

CAT: 0013-GTR19213211Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213211Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DW0254 (DW-0254, DW 0254) is a small molecules capable of inhibiting RAS-related C3 botulinum toxin substrate (RAC) small GTPase activation in ALL cell lines, directly binds to the hydrophobic pocket of PDE6D (Kd=436 nM, ITC), a RAS chaperone protein.DW0254 demonstrated dose-dependent RAC inhibition, arrest of proliferation and induced apoptosis in human leukemic cell lines (RS4;11 IC50=1.5-1.8 uM), also showed promising anti-leukemic activity in RAS-mutated cells (CCRF-CEM NRAS G12D, IC50=3.3-4.2 uM) .DW0254 disrupted the interaction between PDE6D and RAS, disturbing RAS subcellular localization.DW0254 demonstrated anti-leukemic activity, decreased tumor progression in a murine xenograft model.
CAS Number
2031162-89-5
Purity
>98%
Smiles
C (CC (N (CC1C=CC (CC) =CC=1) C) =O) C1OC (=NN=C=1) CCC1=CNC2C=CC=CC1=2
Molecular Formula
C26H28N4O2
Molecular Weight
428.526125907898
Notes
For research use only.

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