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I2906

CAT: 0804-HY-76293-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-76293-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. IC50 Value: Target: Antibacterial Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05) .
CAS Number
331963-29-2
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/I2906.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(C(NNC(CCCCCCCCCCCC)=O)=O)=C(O)C2=CC=CC=C2N1CC
Molecular Formula
C25H37N3O4
Molecular Weight
443.58
References & Citations
[1]Lu, Jingning; Yue, Jun; Wu, Jing et al. In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis. Pharmacology (2010), 85 (6), 365-371.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
MBS3840856-01I2906
A15120-10I2906 10mg
A15120-50I2906 50mg
A15120-25I2906 25mg
A15120-500I2906 500mg
A15120-100I2906 100mg
A15120-10mM-DI2906 10mM * 1mL in DMSO

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