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Efonidipine hydrochloride

CAT: 0013-GTR19212944-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212944-01Size:25 mg
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Description
Efonidipine HCl is a dual T-type and L-type calcium channel blocker with unique pharmacological properties. It enhances dbcAMP-stimulated steroidogenesis in NCI-H295R cells and has demonstrated clinical efficacy in lowering blood pressure without increasing heart rate, while also improving cardiac function in heart failure models.
CAS Number
111011-53-1
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
Cl.O=C (OCCN (C=1C=CC=CC1) CC=2C=CC=CC2) C3=C (NC (=C (C3C=4C=CC=C (C4) N (=O) =O) P5 (=O) OCC (C) (C) CO5) C) C
Molecular Formula
C34H39ClN3O7P
Molecular Weight
668.12
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Efonidipine Hydrochloride

See also: Efonidipine (has active moiety).

CAS Number111011-53-1
PubChem CID119170
IUPAC Name2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;hydrochloride
Molecular FormulaC34H39ClN3O7P
Molecular Weight668.1
Topological Polar Surface Area123
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Heavy Atom Count46
Formal Charge0
Complexity1170
SMILES
CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl
InChI
InChI=1S/C34H38N3O7P.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;1H
InChIKey
OXVTXPCIJDYQIS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Efonidipine Hydrochloride
CAS: 111011-53-1
CID: 119170
Formula: C34H39ClN3O7P
MW: 668.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight668.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass667.2214153
Monoisotopic Mass667.2214153
Topological Polar Surface Area123 Ų
Heavy Atom Count46
Formal Charge0
Complexity1170
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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sc-294464AEfonidipine hydrochloride
HY-12502BEfonidipine (hydrochloride)
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A21431-25Efonidipine hydrochloride 25mg
A21431-100Efonidipine hydrochloride 100mg
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