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NYX-2925

CAT: 0013-GTR19212176-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212176-01Size:25 mg
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Description
NYX-2925 is an orally bioavailable NMDAR modulator that increases activated Src and its phosphorylation at GluN2 subunits in the mPFC. It is used in research for CNS disorders involving NMDA receptor dysfunction, such as neuropathic pain and cognitive deficits, with studies conducted in both in vivo and in vitro models.
CAS Number
2012536-16-0
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
C (C (C) C) (=O) N1[C@]2 (C (=O) N ([C@@H] ([C@@H] (C) O) C (N) =O) C2) CCC1
Molecular Formula
C14H23N3O4
Molecular Weight
297.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Nyx-2925

NYX-2925 is under investigation in clinical trial NCT04146896 (Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy (DPN)).

CAS Number2012536-16-0
PubChem CID122594417
IUPAC Name(2S,3R)-3-hydroxy-2-[(4R)-5-(2-methylpropanoyl)-3-oxo-2,5-diazaspiro[3.4]octan-2-yl]butanamide
Molecular FormulaC14H23N3O4
Molecular Weight297.35
XLogP-0.9
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity479
SMILES
C[C@H]([C@@H](C(=O)N)N1C[C@@]2(C1=O)CCCN2C(=O)C(C)C)O
InChI
InChI=1S/C14H23N3O4/c1-8(2)12(20)17-6-4-5-14(17)7-16(13(14)21)10(9(3)18)11(15)19/h8-10,18H,4-7H2,1-3H3,(H2,15,19)/t9-,10+,14-/m1/s1
InChIKey
NFXPEHLDVKVVKA-ISTVAULSSA-N
Chemical Structure
2D Structure
2D structure of Nyx-2925
CAS: 2012536-16-0
CID: 122594417
Formula: C14H23N3O4
MW: 297.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight297.35
XLogP3-0.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass297.16885622
Monoisotopic Mass297.16885622
Topological Polar Surface Area104 Ų
Heavy Atom Count21
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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