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ZT55

CAT: 0013-GTR19211996-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19211996-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZT55 is a potent and orally bioavailable JAK2 inhibitor (IC50=0.031 μM) effective against JAK2 V617F-driven pathologies. It demonstrates robust anti-proliferative, pro-apoptotic, and cell cycle arrest activity in HEL cells and suppresses tumor growth in HEL xenograft mouse models, supporting research for myeloproliferative neoplasms like polycythemia vera.
CAS Number
2138488-38-5
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C (C (NC1=C (OC) C=CC=C1) =O) C=2C=3C (N (O) C2) =CC=CC3
Molecular Formula
C17H16N2O3
Molecular Weight
296.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-(1-Hydroxy-1H-indol-3-yl)-N-(2-methoxyphenyl)acetamide
CAS Number2138488-38-5
PubChem CID141490249
IUPAC Name2-(1-hydroxyindol-3-yl)-N-(2-methoxyphenyl)acetamide
Molecular FormulaC17H16N2O3
Molecular Weight296.32
XLogP2.8
Topological Polar Surface Area63.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity390
SMILES
COC1=CC=CC=C1NC(=O)CC2=CN(C3=CC=CC=C32)O
InChI
InChI=1S/C17H16N2O3/c1-22-16-9-5-3-7-14(16)18-17(20)10-12-11-19(21)15-8-4-2-6-13(12)15/h2-9,11,21H,10H2,1H3,(H,18,20)
InChIKey
BXYUEIJHUBBZIJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(1-Hydroxy-1H-indol-3-yl)-N-(2-methoxyphenyl)acetamide
CAS: 2138488-38-5
CID: 141490249
Formula: C17H16N2O3
MW: 296.32
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.32
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass296.11609238
Monoisotopic Mass296.11609238
Topological Polar Surface Area63.5 Ų
Heavy Atom Count22
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T73567-01ZT55

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