Products for Research Use Only
RegisterLogin

Pemetrexed Disodium Hydrate

CAT: 0013-GTR19217367-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19217367-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. (In Vitro) :Pemetrexed (LY231514) disodium is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multipie inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Pemetrexed (LY231514) is one of the best substrates that is known for the enzyme FPGS (Km=1.6 μM and Vmax/Km=621) . It is likely that polyglutamation and the polyglutamated metabolites of LY231514 play profound roles in determining both the selectivity and the antitumor activity of this novel agent. Whereas LY23l5l4 only moderately inhibits TS (Ki=340 nM, recombinant mouse), the pentaglutamate of LY23l5l4 is 100-fold more potent (Ki=3.4 nM), making LY231514 one of the most potent folate-based TS inhibitors. (In Vivo) :The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.
CAS Number
357166-30-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 100 mg/mL warmed (193.64 mM)
Smiles
C1=CC (=CC=C1CCC2=CNC3=C2C (=O) N=C (N3) N) C (=O) N[C@@H] (CCC (=O) [O-]) C (=O) [O-].C1=CC (=CC=C1CCC2=CNC3=C2C (=O) N=C (N3) N) C (=O) N[C@@H] (CCC (=O) [O-]) C (=O) [O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]
Molecular Formula
C20H21N5O6·5/2H2O·2Na
Molecular Weight
516.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19172056-01Pemetrexed disodium hemipenta hydrate
GTR19163106-01Pemetrexed disodium
GTR19176375-01Pemetrexed disodium
GTR19257371-01Pemetrexed disodium heptahydrate
GTR19153606-01Pemetrexed Disodium Hemipentahydrate
GTR19234940-01NADH disodium hydrate
GTR19168297-01Phosphocreatine disodium hydrate
GTR19246734-01Glycerophosphate disodium hydrate
GTR19168272-01β-Glycerophosphate disodium salt hydrate
GTR19158954-01Phosphocreatine disodium salt hydrate

Alternative Products

CatalogName
MBS578789Pemetrexed Disodium Hydrate
A3707-100Pemetrexed disodium hemipenta hydrate
GP1390-500mgPemetrexed disodium salt hydrate
HY-13781-01Pemetrexed (disodium hemipenta hydrate)
A15207-5000Pemetrexed disodium hemipenta hydrate 5000mg
A15207-1000Pemetrexed disodium hemipenta hydrate 1000mg
A15207-500Pemetrexed disodium hemipenta hydrate 500mg
HY-13781R-01Pemetrexed (disodium hemipenta hydrate) (Standard)
A15207-200Pemetrexed disodium hemipenta hydrate 200mg
A15207-100Pemetrexed disodium hemipenta hydrate 100mg

Popular Products