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A 438079

CAT: 0013-GTR19216984-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216984-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9) . (In Vitro) :A 438079 blocks BzATP- (10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM in 1321N1 cells stably expressing rat P2X7 receptors. A 438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM. (In Vivo) :In neuropathic rats noxious and innocuous evoked activity of different classes of spinal neurons is reduced by A 438079 (80 μmol/kg, i.v.), and it significantly raises withdrawal thresh-olds in both the SNL and CCI models. A 438079 has superior neuroprotective effects compared with an equal dose of phenobarbital (25 mg/kg) . A 438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behavior scores in the HC model.
CAS Number
899507-36-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (326.64 mM)
Smiles
Clc1cccc (-c2nnnn2Cc2cccnc2) c1Cl
Molecular Formula
C13H9Cl2N5
Molecular Weight
306.15
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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