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Gramicidin S

CAT: 0013-GTR19213195-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213195-01Size:100 mg
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Description
Gramicidin S is an anttiboitics. Gramicidin S reduces the cell number of planktonic cells within 20-40 min at a concentration of 40-80 μg/mL. Gramicidin S kills the cells of pre-grown biofilms at concentrations of 100-200 μg/mL, such that no re-growth is possible. The translocation of the peptide into the cell interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain its anti-biofilm effect. The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of GS. The broad Gramicidin S activity towards resistant, biofilm-forming E. faecalis suggests its applications for approval in root canal medication.
CAS Number
113-73-5
Purity
0.98
Smiles
NCCC[C@@H]1NC (=O) [C@H] (C (C) C) NC (=O) [C@@H]2CCCN2C (=O) [C@@H] (CC2C=CC=CC=2) NC (=O) [C@H] (CC (C) C) NC (=O) [C@H] (CCCN) NC (=O) [C@H] (C (C) C) NC (=O) [C@@H]2CCCN2C (=O) [C@@H] (CC2C=CC=CC=2) NC (=O) [C@H] (CC (C) C) NC1=O
Molecular Formula
C64H94F6N12O14
Molecular Weight
1369.52
Notes
For research use only.

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