BI-0474

CAT: 0013-GTR19210487-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19210487-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

BI-0474 is a potent and selective KRASG12C inhibitor that disrupts the GDP-KRAS::SOS1 interaction (IC50 = 7.0 nM) . It demonstrates robust in vitro antiproliferative activity in NCI-H358 cells and shows significant in vivo anti-tumor efficacy in NSCLC xenograft models, making it a valuable tool for oncology research.

CAS Number

2750570-55-7

Product Name Alternative

KRAS G12C

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Purity

99.61% (May vary between batches)

Smiles

C[C@]1 (C2=C (SC (N) =C2C#N) CCC1) C3=NC (=NO3) C=4N=C (C=C (C4) N5CCN (C (C=C) =O) CC5) N6[C@@H] (C) CN (C) CC6

Molecular Formula

C30H37N9O2S

Molecular Weight

587.74

Storage Conditions

-20°C

Notes

For research use only.

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BA5789-1	BI-0474
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A24574-100	BI-0474 100mg
A24574-50	BI-0474 50mg
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