Products for Research Use Only
RegisterLogin

G108

CAT: 0013-GTR19210352-03Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19210352-03Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
G108 is a selective small molecule inhibitor of human cyclic GMP-AMP synthase (cGAS) . It is a valuable research tool for investigating cGAS-mediated innate immune pathways in autoimmune and inflammatory diseases, applicable in both cellular and animal model studies.
CAS Number
2369750-66-1
Product Name Alternative
G108, G-108, G 108, cGAS, CNP 520, CNP-520, Umibecestat HCl, Umibecestat hydrochloride
Field of Research
Immunology & Inflammation
Purity
99.13% (May vary between batches)
Solubility
H2O:120 mg/mL (328.58 mM)
Smiles
O=C (N1CC=2C=3C (=CC (Cl) =C (Cl) C3NC2CC1) C=4C=NNC4) CO
Molecular Formula
C16H14Cl2N4O2
Molecular Weight
365.21
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one
CAS Number2369750-66-1
PubChem CID138393371
IUPAC Name1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
Molecular FormulaC16H14Cl2N4O2
Molecular Weight365.2
XLogP1.9
Topological Polar Surface Area85
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity497
SMILES
C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CNN=C4)C(=O)CO
InChI
InChI=1S/C16H14Cl2N4O2/c17-11-3-9(8-4-19-20-5-8)14-10-6-22(13(24)7-23)2-1-12(10)21-16(14)15(11)18/h3-5,21,23H,1-2,6-7H2,(H,19,20)
InChIKey
UUDFSTGSYHGEEV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one
CAS: 2369750-66-1
CID: 138393371
Formula: C16H14Cl2N4O2
MW: 365.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.2
XLogP31.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass364.0493811
Monoisotopic Mass364.0493811
Topological Polar Surface Area85 Ų
Heavy Atom Count24
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR18041654-01ASC-1 (G105) polyclonal antibody
GTR18977173SUV39H2 Antibody (G107) Blocking peptide
GTR18064688-01Cleaved-MMP2 (G106) Polyclonal Antibody
GTR18089736Anti-CD8 [G10-1]
GTR18200211Cleaved-MMP-12 (G106) Polyclonal Antibody
GTR19342368Coxsackie A16 (G10 Strain)
GTR18089737Anti-CD8 [G10-1]
GTR18049793-01Cleaved-MMP-12 (G106) rabbit pAb Antibody
GTR19080712-01Recombinant Astyanax fasciatus Green-sensitive opsin-1 (G103)
GTR19080770-01Recombinant Astyanax fasciatus Green-sensitive opsin-2 (G101)

Alternative Products

CatalogName
BUP03423-01G108

Popular Products