Antalarmin

CAT: 0013-GTR19210523-02Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19210523-02Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Antalarmin is a brain-penetrant, selective CRF1 receptor antagonist. It is widely used in neuroscience and inflammation research to study stress-related behaviors and neuroimmune interactions, effectively inhibiting CRF-mediated responses in both in vitro assays and in vivo models like carrageenan-induced inflammation.

CAS Number

157284-96-3

Product Name Alternative

CRHR1

Field of Research

Pharmacology & Drug Discovery

Purity

99.99% (May vary between batches)

Solubility

DMSO:20 mg/mL (52.83 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (5.28 mM)

Smiles

N=1C (=NC (=C2C1N (C=3C (=CC (=CC3C) C) C) C (=C2C) C) N (CC) CCCC) C

Molecular Formula

C24H34N4

Molecular Weight

378.55

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Antalarmin

Antalarmin is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidin-4-amine which is substituted by methyl groups at positions 2, 5, and 6, by a mesityl group at position 7, and in which the amino substituent at position 4 has been substituted by ethyl and butyl groups. It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors (Ki = 1 nM). It has a role as a corticotropin-releasing factor receptor antagonist. It is a pyrrolopyrimidine and a tertiary amino compound.

CAS Number	157284-96-3
PubChem CID	177990
IUPAC Name	N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
Molecular Formula	C24H34N4
Molecular Weight	378.6
XLogP	6.6
Topological Polar Surface Area	34
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Heavy Atom Count	28
Formal Charge	0
Complexity	485

SMILES

CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C

InChI

InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3

InChIKey

IXPROWGEHNVJOY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 157284-96-3

CID: 177990

Formula: C24H34N4

MW: 378.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	378.6
XLogP3	6.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	378.27834710
Monoisotopic Mass	378.27834710
Topological Polar Surface Area	34 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	485
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA5284-5	Antalarmin
HY-103377-01	Antalarmin (hydrochloride)
A24292-10	Antalarmin 10mg
E6536-01	Antalarmin hydrochloride
HY-124475R	Antalarmin (Standard)
A24292-50	Antalarmin 50mg

Antalarmin

Chemical Information

Alternative Products

Popular Products