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(-) -Donepezil

CAT: 0013-GTR19209141-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19209141-01Size:25 mg
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Description
(-) -Donepezil is the enantiomer of the acetylcholinesterase inhibitor Donepezil. This small molecule is widely used in neuroscience research, particularly for in vitro enzyme assays and in vivo studies modeling Alzheimer's disease pathology to investigate cholinergic function.
CAS Number
142057-80-5
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1C=2C (=CC (OC) =C (OC) C2) C[C@@H]1CC3CCN (CC4=CC=CC=C4) CC3
Molecular Formula
C24H29NO3
Molecular Weight
379.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(S)-donepezil

(S)-donepezil is a 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one that has S configuration. It is a conjugate base of a (S)-donepezil(1+). It is an enantiomer of a (R)-donepezil.

CAS Number142057-80-5
PubChem CID969462
IUPAC Name(2S)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Molecular FormulaC24H29NO3
Molecular Weight379.5
XLogP4.3
Topological Polar Surface Area38.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity510
SMILES
COC1=C(C=C2C(=C1)C[C@@H](C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
InChI
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3/t20-/m0/s1
InChIKey
ADEBPBSSDYVVLD-FQEVSTJZSA-N
Chemical Structure
2D Structure
2D structure of (S)-donepezil
CAS: 142057-80-5
CID: 969462
Formula: C24H29NO3
MW: 379.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.5
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass379.21474379
Monoisotopic Mass379.21474379
Topological Polar Surface Area38.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
sc-211231Dehydrodeoxy Donepezil (Donepezil Impurity)
sc-218104Dehydro Donepezil (Donepezil Impurity)
M17876-01Donepezil
447654(-) -Donepezil
574677(+)-Donepezil
T70697-01(+) -Donepezil

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