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Prulifloxacin

CAT: 0804-HY-B0024-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0024-01Size:100 mg
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Description
Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394) . Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis[1][2].
CAS Number
123447-62-1
Product Name Alternative
NM441
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Prulifloxacin.html
Concentration
10mM
Purity
98.05
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C1=C(SC2C)N2C3=C(C=C(F)C(N4CCN(CC5=C(C)OC(O5)=O)CC4)=C3)C1=O)O
Molecular Formula
C21H20FN3O6S
Molecular Weight
461.46
Precautions
H302, H315, H319, H335
References & Citations
[1]M Ozaki, et al. In vivo evaluation of NM441, a new thiazeto-quinoline derivative. Antimicrob Agents Chemother. 1991 Dec;35 (12) :2496-9.|[2]Guillem Prats, et al. Prulifloxacin: a new antibacterial fluoroquinolone. Expert Rev Anti Infect Ther. 2006 Feb;4 (1) :27-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Quinolone

Chemical Information

Prulifloxacin

Prulifloxacin is a quinolone antibiotic and a fluoroquinolone antibiotic.

CAS Number123447-62-1
PubChem CID65947
IUPAC Name6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl]-4-oxo-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
Molecular FormulaC21H20FN3O6S
Molecular Weight461.5
XLogP1
Topological Polar Surface Area125
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Heavy Atom Count32
Formal Charge0
Complexity930
SMILES
CC1N2C3=CC(=C(C=C3C(=O)C(=C2S1)C(=O)O)F)N4CCN(CC4)CC5=C(OC(=O)O5)C
InChI
InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)
InChIKey
PWNMXPDKBYZCOO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Prulifloxacin
CAS: 123447-62-1
CID: 65947
Formula: C21H20FN3O6S
MW: 461.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.5
XLogP31
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass461.10568470
Monoisotopic Mass461.10568470
Topological Polar Surface Area125 Ų
Heavy Atom Count32
Formal Charge0
Complexity930
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
328337Prulifloxacin
ABDPRU10APrulifloxacin (Ulifloxacin)
P10019-500Prulifloxacin (Pruvel)
AR-U01009-01Prulifloxacin-d8
C08255-25mgPrulifloxacin (NM441)

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