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Netarsudil free base

CAT: 0013-GTR19208264-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208264-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Netarsudil (AR-11324) is a potent ROCK inhibitor with Ki values of 1 nM for ROCK1/2. It increases aqueous humor outflow by disrupting actin cytoskeleton and countering TGF-β2 effects in trabecular meshwork cells. In vivo studies in animal models demonstrate its sustained IOP-lowering efficacy with once-daily dosing.
CAS Number
1254032-66-0
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C ([C@H] (CN) C1=CC=C (COC (=O) C2=C (C) C=C (C) C=C2) C=C1) =O) C3=CC4=C (C=C3) C=NC=C4
Molecular Formula
C28H27N3O3
Molecular Weight
453.53
Storage Conditions
-20°C
Notes
For research use only.

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