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Z36

CAT: 0013-GTR19208236-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208236-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Z36 is a novel small molecule Bcl-xL inhibitor that induces autophagic cell death by upregulating FAM134B, LC3, and Atg9. This process triggers ER stress and the unfolded protein response (UPR), making it a useful research tool for studying autophagy and cancer cell death mechanisms in vitro.
CAS Number
1243148-19-7
Smiles
C (=C1C=2C (N (CCCN (C) C) C1=O) =CC=C (F) C2) C=3C=4C (NC3) =CC=C (OC) C4
Molecular Formula
C23H24FN3O2
Molecular Weight
393.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
CAS Number1243148-19-7
PubChem CID137699560
IUPAC Name(3Z)-1-[3-(dimethylamino)propyl]-5-fluoro-3-[(5-methoxy-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-3-yl)methylidene]-3a,4,5,6,7,7a-hexahydroindol-2-one
Molecular FormulaC23H38FN3O2
Molecular Weight407.6
XLogP2.2
Topological Polar Surface Area44.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity625
SMILES
CN(C)CCCN1C2CCC(CC2/C(=C/C3CNC4C3CC(CC4)OC)/C1=O)F
InChI
InChI=1S/C23H38FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h11,15-19,21-22,25H,4-10,12-14H2,1-3H3/b20-11-
InChIKey
NGQQMXCGOOHLQB-JAIQZWGSSA-N
Chemical Structure
2D Structure
2D structure of 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
CAS: 1243148-19-7
CID: 137699560
Formula: C23H38FN3O2
MW: 407.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight407.6
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass407.29480563
Monoisotopic Mass407.29480563
Topological Polar Surface Area44.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity625
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count7
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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