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6RK73

CAT: 0013-GTR19206594-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206594-02Size:5 mg
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Description
6RK73 is a potent, covalent, and irreversible inhibitor that selectively targets UCHL1 with an IC50 of 0.23 μM, demonstrating over 1000-fold selectivity against UCHL3. This small molecule is a valuable chemical probe for studying deubiquitinase function in neurodegenerative disease models and cancer research, both in vitro and in vivo.
CAS Number
1895050-66-4
Product Name Alternative
6RK73, 6RK-73
Field of Research
Cell Biology, Molecular Biology, Protein Biochemistry
Purity
99.91% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.01 mM) ; DMSO:112.5 mg/mL (366.01 mM)
Smiles
O=C (Nc1ncc (s1) N1CCOCC1) [C@H]1CCN (C1) C#N
Molecular Formula
C13H17N5O2S
Molecular Weight
307.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(3S)-1-Cyano-N-(5-morpholin-4-yl-1,3-thiazol-2-yl)pyrrolidine-3-carboxamide
CAS Number1895050-66-4
PubChem CID121248200
IUPAC Name(3S)-1-cyano-N-(5-morpholin-4-yl-1,3-thiazol-2-yl)pyrrolidine-3-carboxamide
Molecular FormulaC13H17N5O2S
Molecular Weight307.37
XLogP1
Topological Polar Surface Area110
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity434
SMILES
C1CN(C[C@H]1C(=O)NC2=NC=C(S2)N3CCOCC3)C#N
InChI
InChI=1S/C13H17N5O2S/c14-9-17-2-1-10(8-17)12(19)16-13-15-7-11(21-13)18-3-5-20-6-4-18/h7,10H,1-6,8H2,(H,15,16,19)/t10-/m0/s1
InChIKey
ONIHSXKWNFYNNS-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of (3S)-1-Cyano-N-(5-morpholin-4-yl-1,3-thiazol-2-yl)pyrrolidine-3-carboxamide
CAS: 1895050-66-4
CID: 121248200
Formula: C13H17N5O2S
MW: 307.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.37
XLogP31
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass307.11029598
Monoisotopic Mass307.11029598
Topological Polar Surface Area110 Ų
Heavy Atom Count21
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3888-106RK73

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