ACY-1083

CAT: 0013-GTR19206555-07Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19206555-07Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ACY-1083 is a potent, selective, and brain-penetrant HDAC6 inhibitor with an IC50 of 3 nM. It is a valuable research tool for studying HDAC6 biology and has demonstrated efficacy in preclinical models for reversing chemotherapy-induced peripheral neuropathy.

CAS Number

1708113-43-2

Product Name Alternative

HDAC6, ACY 1083, ACY1083, ACY-1083

Field of Research

Epigenetics & Chromatin, Molecular Biology

Purity

98.04% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.35 mM) ; DMSO:237.5 mg/mL (681.79 mM)

Smiles

ONC (=O) c1cnc (NC2 (CCC (F) (F) CC2) c2ccccc2) nc1

Molecular Formula

C17H18F2N4O2

Molecular Weight

348.35

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxypyrimidine-5-carboxamide

CAS Number	1708113-43-2
PubChem CID	91844718
IUPAC Name	2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxypyrimidine-5-carboxamide
Molecular Formula	C17H18F2N4O2
Molecular Weight	348.35
XLogP	2.5
Topological Polar Surface Area	87.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Heavy Atom Count	25
Formal Charge	0
Complexity	454

SMILES

C1CC(CCC1(C2=CC=CC=C2)NC3=NC=C(C=N3)C(=O)NO)(F)F

InChI

InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)

InChIKey

MRWCVKLVSWYIFO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1708113-43-2

CID: 91844718

Formula: C17H18F2N4O2

MW: 348.35

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	348.35
XLogP3	2.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	348.13978215
Monoisotopic Mass	348.13978215
Topological Polar Surface Area	87.1 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	454
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA4124-5	ACY-1083
A19985-50	ACY-1083 50mg
A19985-1	ACY-1083 1mg
A19985-100	ACY-1083 100mg
A19985-10	ACY-1083 10mg
A19985-5	ACY-1083 5mg
A19985-500	ACY-1083 500mg
A19985-25	ACY-1083 25mg
A19985-10mM-D	ACY-1083 10mM * 1mL in DMSO
BA4125-5	ACY-957

ACY-1083

Chemical Information

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