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CH6953755

CAT: 0013-GTR19206243-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206243-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CH6953755 is a potent and selective oral YES1 kinase inhibitor with an IC50 of 1.8 nM. It suppresses cancer cell proliferation in vitro and demonstrates antitumor efficacy in vivo, making it a valuable research tool for oncology studies targeting YES1-dependent signaling pathways.
CAS Number
2055918-71-1
Product Name Alternative
CH-6953755, CH6953755, CH 6953755, Yes1, YES1
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.03% (May vary between batches)
Solubility
DMSO:100 mg/mL (180.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.24 mM)
Smiles
Cc1cc2cc ([nH]c2cc1NS (C) (=O) =O) C (=O) c1cnn (c1N) -c1cnc (Oc2c (F) cccc2F) cc1C
Molecular Formula
C26H22F2N6O4S
Molecular Weight
552.55
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[2-[5-Amino-1-[6-(2,6-difluorophenoxy)-4-methylpyridin-3-yl]pyrazole-4-carbonyl]-5-methyl-1H-indol-6-yl]methanesulfonamide
CAS Number2055918-71-1
PubChem CID124149825
IUPAC NameN-[2-[5-amino-1-[6-(2,6-difluorophenoxy)-4-methyl-3-pyridinyl]pyrazole-4-carbonyl]-5-methyl-1H-indol-6-yl]methanesulfonamide
Molecular FormulaC26H22F2N6O4S
Molecular Weight552.6
XLogP4.6
Topological Polar Surface Area153
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count39
Formal Charge0
Complexity978
SMILES
CC1=CC2=C(C=C1NS(=O)(=O)C)NC(=C2)C(=O)C3=C(N(N=C3)C4=CN=C(C=C4C)OC5=C(C=CC=C5F)F)N
InChI
InChI=1S/C26H22F2N6O4S/c1-13-7-15-9-21(32-20(15)10-19(13)33-39(3,36)37)24(35)16-11-31-34(26(16)29)22-12-30-23(8-14(22)2)38-25-17(27)5-4-6-18(25)28/h4-12,32-33H,29H2,1-3H3
InChIKey
YVXUHNOWRKWXSJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[2-[5-Amino-1-[6-(2,6-difluorophenoxy)-4-methylpyridin-3-yl]pyrazole-4-carbonyl]-5-methyl-1H-indol-6-yl]methanesulfonamide
CAS: 2055918-71-1
CID: 124149825
Formula: C26H22F2N6O4S
MW: 552.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight552.6
XLogP34.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass552.13913070
Monoisotopic Mass552.13913070
Topological Polar Surface Area153 Ų
Heavy Atom Count39
Formal Charge0
Complexity978
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA9012-50CH6953755

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