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CM-675

CAT: 0013-GTR19206194-08Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206194-08Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CM-675 is a dual-target small molecule inhibitor of PDE5 and class I HDACs, exhibiting IC50 values of 114 nM and 673 nM against PDE5 and HDAC1, respectively. It has shown potential in Alzheimer's disease research, with studies indicating neuroprotective effects and cognitive improvement in preclinical in vivo models.
CAS Number
1872466-47-1
Product Name Alternative
CM675, CM-675, CM 675, PDE5
Field of Research
Epigenetics & Chromatin, Metabolism Research, Molecular Biology
Purity
99.67% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.86 mM) ; DMSO:22.5 mg/mL (41.93 mM)
Smiles
CCCc1nn (C) c2c1nc ([nH]c2=O) -c1cc (Cc2ccc (cc2) C (=O) Nc2ccccc2N) ccc1OCC
Molecular Formula
C31H32N6O3
Molecular Weight
536.62
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]benzamide
CAS Number1872466-47-1
PubChem CID136955224
IUPAC NameN-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,5-d]pyrimidin-5-yl)phenyl]methyl]benzamide
Molecular FormulaC31H32N6O3
Molecular Weight536.6
XLogP4.6
Topological Polar Surface Area124
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count40
Formal Charge0
Complexity906
SMILES
CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C
InChI
InChI=1S/C31H32N6O3/c1-4-8-25-27-28(37(3)36-25)31(39)35-29(34-27)22-18-20(13-16-26(22)40-5-2)17-19-11-14-21(15-12-19)30(38)33-24-10-7-6-9-23(24)32/h6-7,9-16,18H,4-5,8,17,32H2,1-3H3,(H,33,38)(H,34,35,39)
InChIKey
IUKGCTNFPZAWGC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]benzamide
CAS: 1872466-47-1
CID: 136955224
Formula: C31H32N6O3
MW: 536.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight536.6
XLogP34.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass536.25358890
Monoisotopic Mass536.25358890
Topological Polar Surface Area124 Ų
Heavy Atom Count40
Formal Charge0
Complexity906
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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