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CMLD012073

CAT: 0013-GTR19206188-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206188-02Size:50 mg
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Description
CMLD012073 is a potent and selective small molecule inhibitor of the eukaryotic initiation factor 4A (eIF4A) RNA helicase, disrupting translation initiation. It exhibits potent activity in cellular models like NIH/3T3 cells (IC50: 10 nM) and is a valuable chemical probe for studying protein synthesis, oncogene expression, and cancer biology in vitro.
CAS Number
2368900-32-5
Field of Research
Cell Biology
Smiles
O[C@@]12[C@@]3 ([C@] ([C@@H] ([C@H]1C (OC) =O) C4=CC=CC=C4) (OC=5C3=C (OC) C=C (OC) C5) C6=CC=C (OC) C=C6) NC (C) =N2
Molecular Formula
C30H30N2O7
Molecular Weight
530.57
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 145712381
CAS Number2368900-32-5
PubChem CID145712381
IUPAC Namemethyl (1R,9R,10S,11R,12R)-12-hydroxy-3,5-dimethoxy-9-(4-methoxyphenyl)-14-methyl-10-phenyl-8-oxa-13,15-diazatetracyclo[7.6.0.01,12.02,7]pentadeca-2(7),3,5,14-tetraene-11-carboxylate
Molecular FormulaC30H30N2O7
Molecular Weight530.6
XLogP3
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count39
Formal Charge0
Complexity963
SMILES
CC1=N[C@]23C4=C(C=C(C=C4OC)OC)O[C@]2([C@@H]([C@H]([C@@]3(N1)O)C(=O)OC)C5=CC=CC=C5)C6=CC=C(C=C6)OC
InChI
InChI=1S/C30H30N2O7/c1-17-31-29-25-22(37-4)15-21(36-3)16-23(25)39-28(29,19-11-13-20(35-2)14-12-19)24(18-9-7-6-8-10-18)26(27(33)38-5)30(29,34)32-17/h6-16,24,26,34H,1-5H3,(H,31,32)/t24-,26+,28+,29-,30-/m1/s1
InChIKey
YEBNUTRZELOAAC-JFYVELCSSA-N
Chemical Structure
2D Structure
2D structure of CID 145712381
CAS: 2368900-32-5
CID: 145712381
Formula: C30H30N2O7
MW: 530.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight530.6
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass530.20530130
Monoisotopic Mass530.20530130
Topological Polar Surface Area108 Ų
Heavy Atom Count39
Formal Charge0
Complexity963
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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