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CRA-026440

CAT: 0013-GTR19206152-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206152-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CRA-026440 (PCI-34051) is a potent, pan-HDAC inhibitor targeting multiple isoforms, including HDAC1, 2, 3, 6, 8, and 10, with Ki values in the low nanomolar range. It exhibits anti-tumor and anti-angiogenic properties, making it a useful research tool for studying colon cancer in both cellular and animal models.
CAS Number
847460-34-8
Product Name Alternative
CRA026440, CRA-026440, CRA 026440, PCI-34051, HDAC8, HDAC, HDAC2, HDAC3, HDAC6, HDAC1, HDAC10
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
96.42% (May vary between batches)
Solubility
DMSO:90 mg/mL (214.05 mM)
Smiles
O=C (NO) C1=CC=C (C#CCNC (=O) C2=CC=3C=C (OCCN (C) C) C=CC3N2) C=C1
Molecular Formula
C23H24N4O4
Molecular Weight
420.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cra-026440

has both antineoplastic and antiangiogenic activities; structure in first source

CAS Number847460-34-8
PubChem CID11619470
IUPAC Name5-[2-(dimethylamino)ethoxy]-N-[3-[4-(hydroxycarbamoyl)phenyl]prop-2-ynyl]-1H-indole-2-carboxamide
Molecular FormulaC23H24N4O4
Molecular Weight420.5
XLogP2.3
Topological Polar Surface Area107
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity678
SMILES
CN(C)CCOC1=CC2=C(C=C1)NC(=C2)C(=O)NCC#CC3=CC=C(C=C3)C(=O)NO
InChI
InChI=1S/C23H24N4O4/c1-27(2)12-13-31-19-9-10-20-18(14-19)15-21(25-20)23(29)24-11-3-4-16-5-7-17(8-6-16)22(28)26-30/h5-10,14-15,25,30H,11-13H2,1-2H3,(H,24,29)(H,26,28)
InChIKey
OHUCIUMMEAYVKS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cra-026440
CAS: 847460-34-8
CID: 11619470
Formula: C23H24N4O4
MW: 420.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight420.5
XLogP32.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass420.17975526
Monoisotopic Mass420.17975526
Topological Polar Surface Area107 Ų
Heavy Atom Count31
Formal Charge0
Complexity678
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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