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JAK2-IN-4

CAT: 0013-GTR19206457-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206457-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK2-IN-4 is a potent and selective small molecule inhibitor targeting JAK2 and JAK3 kinases, exhibiting IC50 values of 0.7 nM and 23.2 nM, respectively. It is a valuable research tool for investigating JAK-STAT signaling in hematological malignancies and immune disorders in both cellular and animal models.
CAS Number
1438284-00-4
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
CC=1C (C2=CC3=C (O2) CCN (S (C) (=O) =O) C3) =NC (NC4=CC=C (C=C4) N5CCOCC5) =NC1
Molecular Formula
C23H27N5O4S
Molecular Weight
469.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Jak2-IN-4
CAS Number1438284-00-4
PubChem CID76072368
IUPAC Name5-methyl-4-(5-methylsulfonyl-6,7-dihydro-4H-furo[3,2-c]pyridin-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
Molecular FormulaC23H27N5O4S
Molecular Weight469.6
XLogP2.1
Topological Polar Surface Area109
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity750
SMILES
CC1=CN=C(N=C1C2=CC3=C(O2)CCN(C3)S(=O)(=O)C)NC4=CC=C(C=C4)N5CCOCC5
InChI
InChI=1S/C23H27N5O4S/c1-16-14-24-23(25-18-3-5-19(6-4-18)27-9-11-31-12-10-27)26-22(16)21-13-17-15-28(33(2,29)30)8-7-20(17)32-21/h3-6,13-14H,7-12,15H2,1-2H3,(H,24,25,26)
InChIKey
YDZHOVOPBMIATL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Jak2-IN-4
CAS: 1438284-00-4
CID: 76072368
Formula: C23H27N5O4S
MW: 469.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.6
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass469.17837553
Monoisotopic Mass469.17837553
Topological Polar Surface Area109 Ų
Heavy Atom Count33
Formal Charge0
Complexity750
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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