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Mcl-1 inhibitor 3

CAT: 0013-GTR19205444Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205444Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This macrocyclic compound is a highly potent and orally bioavailable Mcl-1 inhibitor, demonstrating sub-nanomolar binding affinity (Ki=0.061 nM) and cellular activity (IC50=19 nM in OPM-2 cells) . It exhibits favorable pharmacokinetics and has shown excellent in vivo efficacy in research models without reported toxicity, making it a valuable tool for studying apoptosis and cancer biology.
CAS Number
2376774-73-9
Field of Research
Cell Biology, Pharmacology & Drug Discovery; Cell Biology
Smiles
[H][C@@]12CC[C@@]1 ([H]) [C@@H] (OCCN1CC (F) (F) C1) \C=C/CCN (C) C (=O) C[C@] (O) (C (=O) NS (=O) (=O) N (C) C) c1ccc3OC[C@]4 (CCCc5cc (Cl) ccc45) CN (C2) c3c1 |c:18|
Molecular Formula
C40H52ClF2N5O7S
Molecular Weight
820.39
Storage Conditions
-20°C
Notes
For research use only.

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