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MK-7145

CAT: 0013-GTR19205385-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205385-03Size:100 mg
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Description
MK-7145 is a potent and selective small-molecule inhibitor of the renal outer medullary potassium channel (ROMK), exhibiting an IC50 of 45 nM. It serves as a valuable pharmacological tool for investigating renal electrolyte balance, blood pressure regulation, and diuretic mechanisms in both cellular and animal models.
CAS Number
1255204-84-2
Field of Research
Pharmacology & Drug Discovery
Smiles
CC1=C2C (C (=O) OC2) =CC=C1[C@H] (CN3CCN (C[C@H] (O) C=4C (C) =C5C (=CC4) C (=O) OC5) CC3) O
Molecular Formula
C26H30N2O6
Molecular Weight
466.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mk-7145

MK-7145 has been used in trials studying the treatment of Hypertension and Renal Insufficiency.

CAS Number1255204-84-2
PubChem CID59568713
IUPAC Name5-[(1R)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Molecular FormulaC26H30N2O6
Molecular Weight466.5
XLogP1.3
Topological Polar Surface Area99.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity694
SMILES
CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCN(CC3)C[C@@H](C4=C(C5=C(C=C4)C(=O)OC5)C)O)O
InChI
InChI=1S/C26H30N2O6/c1-15-17(3-5-19-21(15)13-33-25(19)31)23(29)11-27-7-9-28(10-8-27)12-24(30)18-4-6-20-22(16(18)2)14-34-26(20)32/h3-6,23-24,29-30H,7-14H2,1-2H3/t23-,24-/m0/s1
InChIKey
OCKGFTQIICXDQW-ZEQRLZLVSA-N
Chemical Structure
2D Structure
2D structure of Mk-7145
CAS: 1255204-84-2
CID: 59568713
Formula: C26H30N2O6
MW: 466.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight466.5
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass466.21038668
Monoisotopic Mass466.21038668
Topological Polar Surface Area99.5 Ų
Heavy Atom Count34
Formal Charge0
Complexity694
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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MBS3845463-01MK-7145
A21030-10MK-7145 10mg
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A21030-5MK-7145 5mg
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