PrPSc-IN-1

CAT: 0013-GTR19205061-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19205061-02Size:50 mg

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Description

PrPSc-IN-1 is a fluorescent small molecule probe that selectively binds to misfolded prion protein (PrPSc) . It inhibits PrPSc accumulation with an IC50 of 1.6 μM, demonstrating anti-prion activity useful for both in vitro detection assays and in vivo therapeutic research in prion disease models.

CAS Number

1315475-30-9

Field of Research

Immunology & Inflammation

Smiles

COc1ccc2c (c1) nc (NN=Cc1ccnc3ccccc13) c1cccn21

Molecular Formula

C22H17N5O

Molecular Weight

367.40

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

PrPSc-IN-1

CAS Number	1315475-30-9
PubChem CID	53497238
IUPAC Name	7-methoxy-N-[(E)-quinolin-4-ylmethylideneamino]pyrrolo[1,2-a]quinoxalin-4-amine
Molecular Formula	C22H17N5O
Molecular Weight	367.4
XLogP	5
Topological Polar Surface Area	63.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	28
Formal Charge	0
Complexity	557

SMILES

COC1=CC2=C(C=C1)N3C=CC=C3C(=N2)N/N=C/C4=CC=NC5=CC=CC=C45

InChI

InChI=1S/C22H17N5O/c1-28-16-8-9-20-19(13-16)25-22(21-7-4-12-27(20)21)26-24-14-15-10-11-23-18-6-3-2-5-17(15)18/h2-14H,1H3,(H,25,26)/b24-14+

InChIKey

XNOPJZJRRJXDPO-ZVHZXABRSA-N

Chemical Structure

2D Structure

CAS: 1315475-30-9

CID: 53497238

Formula: C22H17N5O

MW: 367.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	367.4
XLogP3	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	367.14331018
Monoisotopic Mass	367.14331018
Topological Polar Surface Area	63.8 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	557
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MBS3844933-01	PrPSc-IN-1
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A20488-1	PrPSc-IN-1 1mg
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PrPSc-IN-1

Chemical Information

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