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Toceranib

CAT: 0013-GTR19204611-04Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204611-04Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Toceranib phosphate is an orally bioavailable, small molecule tyrosine kinase inhibitor targeting PDGFR, VEGFR, and Kit with high potency. It exhibits antitumor and antiangiogenic activity, making it a useful research tool for studying oncology and angiogenesis in both cellular and animal models.
CAS Number
356068-94-5
Product Name Alternative
CD117, c-Kit, cKit, Inhibitor, Flk-1, inhibit, Kit, PDGFRβ, PDGFR, Platelet-derived growth factor receptor, Vascular endothelial growth factor receptor, VEGFR, SCFR, SU11654, SU-11654, SU 11654, Toceranib, PHA 291639E
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.14% (May vary between batches)
Solubility
DMSO:2.4 mg/mL (6.05 mM)
Smiles
Cc1[nH]c (\C=C2/C (=O) Nc3ccc (F) cc23) c (C) c1C (=O) NCCN1CCCC1
Molecular Formula
C22H25FN4O2
Molecular Weight
396.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Toceranib

See also: Toceranib Phosphate (active moiety of).

CAS Number356068-94-5
PubChem CID5329106
IUPAC Name5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
Molecular FormulaC22H25FN4O2
Molecular Weight396.5
XLogP2.4
Topological Polar Surface Area77.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity663
SMILES
CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)/C=C\3/C4=C(C=CC(=C4)F)NC3=O
InChI
InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
InChIKey
SRSGVKWWVXWSJT-ATVHPVEESA-N
Chemical Structure
2D Structure
2D structure of Toceranib
CAS: 356068-94-5
CID: 5329106
Formula: C22H25FN4O2
MW: 396.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight396.5
XLogP32.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass396.19615422
Monoisotopic Mass396.19615422
Topological Polar Surface Area77.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity663
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1542-25Toceranib
HY-10330A-01Toceranib (phosphate)
MBS3840970-01Toceranib phosphate
TRC-T525502-100MGToceranib-d8
467694-01Toceranib discontinued

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