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Tyk2-IN-5

CAT: 0013-GTR19204570-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204570-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyk2-IN-5 is a potent, orally bioavailable small molecule inhibitor selectively targeting the Tyk2 JH2 pseudokinase domain with a Ki of 0.086 nM. It demonstrates functional activity in cellular assays, inhibiting IFNα signaling with an IC50 of 25 nM, making it a valuable chemical probe for studying JAK-STAT pathways in autoimmune and inflammatory disease research.
CAS Number
1797432-62-2
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
CNc1cc (Nc2cccn (-c3ccccn3) c2=O) nn2c (cnc12) C (=O) N[C@@H]1C[C@@H]1F
Molecular Formula
C21H19FN8O2
Molecular Weight
434.43
Storage Conditions
-20°C
Notes
For research use only.

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