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ZD-0892

CAT: 0013-GTR19205434-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205434-02Size:5 mg
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Description
ZD-0892 is a potent and selective neutrophil elastase inhibitor effective against both human and porcine pancreatic elastase. It has demonstrated efficacy in reversing advanced pulmonary vascular disease in rat models, making it a valuable research tool for studying COPD and peripheral vascular disease pathogenesis.
CAS Number
171964-73-1
Product Name Alternative
Human neutrophil elastase, neutrophil elastase, Serine Protease, SerineProtease, ZD 0892, ZD0892, ZD-0892
Field of Research
Protein Biochemistry
Purity
95.00% (May vary between batches)
Solubility
DMSO:150 mg/mL (300.29 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.01 mM)
Smiles
COc1ccc (cc1) C (=O) N[C@@H] (C (C) C) C (=O) N1CCC[C@H]1C (=O) N[C@@H] (C (C) C) C (=O) C (F) (F) F
Molecular Formula
C24H32F3N3O5
Molecular Weight
499.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

ZD-0892

a trifluoromethyl ketone-based; structure in first source

CAS Number171964-73-1
PubChem CID9892148
IUPAC Name(2S)-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]pyrrolidine-2-carboxamide
Molecular FormulaC24H32F3N3O5
Molecular Weight499.5
XLogP4.2
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity779
SMILES
CC(C)[C@@H](C(=O)C(F)(F)F)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)C2=CC=C(C=C2)OC
InChI
InChI=1S/C24H32F3N3O5/c1-13(2)18(20(31)24(25,26)27)28-22(33)17-7-6-12-30(17)23(34)19(14(3)4)29-21(32)15-8-10-16(35-5)11-9-15/h8-11,13-14,17-19H,6-7,12H2,1-5H3,(H,28,33)(H,29,32)/t17-,18-,19-/m0/s1
InChIKey
PNILZVBINXNWHW-FHWLQOOXSA-N
Chemical Structure
2D Structure
2D structure of ZD-0892
CAS: 171964-73-1
CID: 9892148
Formula: C24H32F3N3O5
MW: 499.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight499.5
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass499.22940562
Monoisotopic Mass499.22940562
Topological Polar Surface Area105 Ų
Heavy Atom Count35
Formal Charge0
Complexity779
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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