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Recombinant Human SOX2-TAT

CAT: 0355-AP60465Size: InquireDry Ice: NoHazardous: No
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CAT#:0355-AP60465Size:Inquire
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Background
Sox2, also named SRY (sex determining region Y) -box 2, is belonging to the Sox family and it is encoded by the Sox gene in human. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids. Sox2 plays a role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine. Mature human Sox2 shares 100 amino acid sequence identity with murine and rat Sox2. Recombinant human Sox2-TAT expressed in E. coli is a 36 kDa protein containing 330 amino-acid residues, including the 317 residues of full-length Sox2 and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR) .
Product Name Alternative
SOX2-TAT
Gene ID
6657
UniProt
P48431
Target
MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHMGGY GRKKRRQRRR
Purification
> 95 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ugof rHuSOX2-TAT as determined by LAL method.
Bioactivity
Data Not Available.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 36.0 kDa, a single non-glycosylated polypeptide chain containing 330 amino acids, including the 317 residues of full-length Sox2 and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR) .
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 2 x PBS, pH 7.4, with 5% Trehalose.
Host or Source
Escherichia coli

UniProtKB · P48431

Transcription factor SOX-2

SOX2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48431
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOX2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q14537
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantMicrophthalmia

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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