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1G244

CAT: 0013-GTR19204140-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204140-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1G244 is a potent and selective inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9), exhibiting nanomolar-range IC50 and Ki values. This compound has demonstrated antiatherosclerotic and antimyeloma properties in research, supporting its use in studying inflammation, cancer biology, and metabolic diseases in both cellular and animal models.
CAS Number
847928-32-9
Product Name Alternative
1G 244, 1G244, 1G-244, DPP8, DPP9
Field of Research
Cell Biology, Protein Biochemistry
Purity
98.23% (May vary between batches)
Solubility
DMSO:225 mg/mL (445.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.91 mM)
Smiles
N[C@@H] (CC (=O) N1CCN (CC1) C (c1ccc (F) cc1) c1ccc (F) cc1) C (=O) N1Cc2ccccc2C1
Molecular Formula
C29H30F2N4O2
Molecular Weight
504.57
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1G244
CAS Number847928-32-9
PubChem CID56658139
IUPAC Name(2S)-2-amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione
Molecular FormulaC29H30F2N4O2
Molecular Weight504.6
XLogP2.5
Topological Polar Surface Area69.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count37
Formal Charge0
Complexity740
SMILES
C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N
InChI
InChI=1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2/t26-/m0/s1
InChIKey
ZKIQFLSGMMYCGS-SANMLTNESA-N
Chemical Structure
2D Structure
2D structure of 1G244
CAS: 847928-32-9
CID: 56658139
Formula: C29H30F2N4O2
MW: 504.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight504.6
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass504.23368254
Monoisotopic Mass504.23368254
Topological Polar Surface Area69.9 Ų
Heavy Atom Count37
Formal Charge0
Complexity740
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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