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AZD8797

CAT: 0013-GTR19203981-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203981-01Size:1 mg
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Description
AZD8797 (KAND567) is a selective, orally bioavailable antagonist of human CX3CR1 and CXCR2. It has shown potential in research models to protect against SARS-CoV-2-related neuronal damage and to attenuate migraine-associated nociceptive sensitization and microglial activation in post-seizure rats.
CAS Number
911715-90-7
Product Name Alternative
CX3CR1, CXCR2, AZD 8797, AZD8797, AZD-8797, [125I]-CX3CL1-CX3CR1, 125I-IL-8-CXCR2, KAN-0440567, KAND567
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
98.73% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.91 mM) ; DMSO:100 mg/mL (247.79 mM)
Smiles
CC (C) C[C@H] (CO) Nc1nc (S[C@@H] (C) c2ccccc2) nc2nc (N) sc12
Molecular Formula
C19H25N5OS2
Molecular Weight
403.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Rugocrixan

KAND567, a small molecule, blocks the fractaline (CX3CL1) receptor, which mediates the immune system response to inflammation. Because COVID-19 involves cytotoxic cells associated with this pathway, KAND567 is currently being tested as a treatment for those with the illness.

CAS Number911715-90-7
PubChem CID11965767
IUPAC Name(2R)-2-[[2-amino-5-[(1S)-1-phenylethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Molecular FormulaC19H25N5OS2
Molecular Weight403.6
XLogP4.8
Topological Polar Surface Area150
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count27
Formal Charge0
Complexity452
SMILES
C[C@@H](C1=CC=CC=C1)SC2=NC3=C(C(=N2)N[C@H](CC(C)C)CO)SC(=N3)N
InChI
InChI=1S/C19H25N5OS2/c1-11(2)9-14(10-25)21-16-15-17(22-18(20)27-15)24-19(23-16)26-12(3)13-7-5-4-6-8-13/h4-8,11-12,14,25H,9-10H2,1-3H3,(H3,20,21,22,23,24)/t12-,14+/m0/s1
InChIKey
ZMQSLMZOWVGBSM-GXTWGEPZSA-N
Chemical Structure
2D Structure
2D structure of Rugocrixan
CAS: 911715-90-7
CID: 11965767
Formula: C19H25N5OS2
MW: 403.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight403.6
XLogP34.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass403.15005279
Monoisotopic Mass403.15005279
Topological Polar Surface Area150 Ų
Heavy Atom Count27
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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