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BI605906

CAT: 0013-GTR19203931-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203931-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI605906 is a selective IKKβ inhibitor that blocks TNF-α-induced IκB degradation and subsequent IL-6 production. This mechanism supports its application in studying NF-κB-driven inflammatory pathways, with research utility in both cellular models and animal studies of conditions like psoriasis.
CAS Number
960293-88-3
Product Name Alternative
BI605906, BI-605906, BI 605906, at 0.1 mM ATP, IKK, IkB/IKK, IkB, IκB, ILReceptor, IL-6, IKKβ, IL Receptor
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
97.14% (May vary between batches)
Solubility
DMSO:40 mg/mL (92.48 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.31 mM)
Smiles
CCC (F) (F) c1cc (nc2sc (C (N) =O) c (N) c12) N1CCC (CC1) S (C) (=O) =O
Molecular Formula
C17H22F2N4O3S2
Molecular Weight
432.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

BI605906

IKK (IκB(inhibitor of NF-κB (nuclear factor κB)) kinase) family inhibitor; structure in first source

CAS Number960293-88-3
PubChem CID23652660
IUPAC Name3-amino-4-(1,1-difluoropropyl)-6-(4-methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide
Molecular FormulaC17H22F2N4O3S2
Molecular Weight432.5
XLogP3
Topological Polar Surface Area156
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity695
SMILES
CCC(C1=CC(=NC2=C1C(=C(S2)C(=O)N)N)N3CCC(CC3)S(=O)(=O)C)(F)F
InChI
InChI=1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24)
InChIKey
IYHHRZBKXXKDDY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of BI605906
CAS: 960293-88-3
CID: 23652660
Formula: C17H22F2N4O3S2
MW: 432.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight432.5
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass432.11013925
Monoisotopic Mass432.11013925
Topological Polar Surface Area156 Ų
Heavy Atom Count28
Formal Charge0
Complexity695
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8602-100BI605906
A13537-5BI605906 5mg
A13537-1BI605906 1mg
A13537-50BI605906 50mg
A13537-10BI605906 10mg
A13537-25BI605906 25mg
A13537-200BI605906 200mg
A13537-100BI605906 100mg
A13537-10mM-DBI605906 10mM * 1mL in DMSO

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