Bz 423

CAT: 0013-GTR19203874-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19203874-02Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Bz-423 is a potent immunomodulatory small molecule that induces apoptosis via Bax/Bak activation, leading to mitochondrial outer membrane permeabilization and cytochrome c release. It has demonstrated partial efficacy in a murine lupus model, supporting its research use in studying autoimmune diseases and mitochondrial apoptosis pathways.

CAS Number

216691-95-1

Product Name Alternative

Bz 423, BZ 48, BZ48, BZ-48, Bax, Bak, Apoptosis

Field of Research

Cell Biology

Purity

98.89% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.48 mM) ; DMSO:80 mg/mL (181.44 mM)

Smiles

CN1c2ccc (Cl) cc2C (=NC (Cc2ccc3ccccc3c2) C1=O) c1ccc (O) cc1

Molecular Formula

C27H21ClN2O2

Molecular Weight

440.92

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Bz-423

CAS Number	216691-95-1
PubChem CID	644335
IUPAC Name	7-chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-3H-1,4-benzodiazepin-2-one
Molecular Formula	C27H21ClN2O2
Molecular Weight	440.9
XLogP	5.6
Topological Polar Surface Area	52.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	32
Formal Charge	0
Complexity	704

SMILES

CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)CC3=CC4=CC=CC=C4C=C3)C5=CC=C(C=C5)O

InChI

InChI=1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,31H,15H2,1H3

InChIKey

HIJCSNHREFFOML-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 216691-95-1

CID: 644335

Formula: C27H21ClN2O2

MW: 440.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	440.9
XLogP3	5.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	440.1291556
Monoisotopic Mass	440.1291556
Topological Polar Surface Area	52.9 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	704
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Bz 423

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