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CBS9106

CAT: 0013-GTR19203862-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203862-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CBS9106 (SL-801) is a reversible oral CRM1 inhibitor that blocks CRM1-dependent nuclear export and induces CRM1 degradation. It demonstrates antitumor activity, inhibiting tumor growth and prolonging survival in mouse xenograft models, supporting its use in oncology research for both in vitro and in vivo studies.
CAS Number
1076235-04-5
Product Name Alternative
CRM1, CBS9106, CBS-9106, CBS 9106, Felezonexor, SL801, SL-801, SL 801
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.98% (May vary between batches)
Smiles
O=C1C (=C (C (=O) N1NC2=NC (Cl) =C (C=C2) C (F) (F) F) COCCC (C) (C) C) C
Molecular Formula
C18H21ClF3N3O3
Molecular Weight
419.83
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Felezonexor

Felezonexor is a small molecule drug. The usage of the INN stem '-nexor' in the name indicates that Felezonexor is a nuclear export inhibitor. Felezonexor is under investigation in clinical trial NCT02667873 (A Trial of a Novel XPO1 Inhibitor in Participants With Advanced Solid Tumors). Felezonexor has a monoisotopic molecular weight of 419.12 Da.

CAS Number1076235-04-5
PubChem CID25103750
IUPAC Name1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-(3,3-dimethylbutoxymethyl)-4-methylpyrrole-2,5-dione
Molecular FormulaC18H21ClF3N3O3
Molecular Weight419.8
XLogP4.6
Topological Polar Surface Area71.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity646
SMILES
CC1=C(C(=O)N(C1=O)NC2=NC(=C(C=C2)C(F)(F)F)Cl)COCCC(C)(C)C
InChI
InChI=1S/C18H21ClF3N3O3/c1-10-11(9-28-8-7-17(2,3)4)16(27)25(15(10)26)24-13-6-5-12(14(19)23-13)18(20,21)22/h5-6H,7-9H2,1-4H3,(H,23,24)
InChIKey
CMASLSTVVOYJQY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Felezonexor
CAS: 1076235-04-5
CID: 25103750
Formula: C18H21ClF3N3O3
MW: 419.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight419.8
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass419.1223537
Monoisotopic Mass419.1223537
Topological Polar Surface Area71.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity646
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T14885-01CBS9106
A19643-1CBS9106 1mg
A19643-10CBS9106 10mg
A19643-5CBS9106 5mg
A19643-50CBS9106 50mg
A19643-25CBS9106 25mg

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