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ITX3

CAT: 0013-GTR19203744-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203744-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITX3 is a potent and selective inhibitor of the TrioN RhoGEF domain, exhibiting an IC50 of 76 μM. It effectively blocks Trio-mediated activation of RhoG and Rac1 GTPases, which underlies its utility in studying cell morphology, neurite outgrowth in PC12 cells, and fibroblast structural changes in vitro.
CAS Number
347323-96-0
Product Name Alternative
ITX 3, ITX3, ITX-3, Rho GEFs
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.28% (May vary between batches)
Solubility
DMSO:4 mg/mL (10.77 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cc (\C=c2\sc3nc4ccccc4n3c2=O) c (C) n1-c1ccccc1
Molecular Formula
C22H17N3OS
Molecular Weight
371.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one
CAS Number347323-96-0
PubChem CID1362865
IUPAC Name(2E)-2-[(2,5-dimethyl-1-phenylpyrrol-3-yl)methylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1-one
Molecular FormulaC22H17N3OS
Molecular Weight371.5
XLogP5.3
Topological Polar Surface Area65.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count27
Formal Charge0
Complexity617
SMILES
CC1=CC(=C(N1C2=CC=CC=C2)C)/C=C/3\C(=O)N4C5=CC=CC=C5N=C4S3
InChI
InChI=1S/C22H17N3OS/c1-14-12-16(15(2)24(14)17-8-4-3-5-9-17)13-20-21(26)25-19-11-7-6-10-18(19)23-22(25)27-20/h3-13H,1-2H3/b20-13+
InChIKey
SJMYMKPBODEZSH-DEDYPNTBSA-N
Chemical Structure
2D Structure
2D structure of (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one
CAS: 347323-96-0
CID: 1362865
Formula: C22H17N3OS
MW: 371.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight371.5
XLogP35.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass371.10923335
Monoisotopic Mass371.10923335
Topological Polar Surface Area65.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity617
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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