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M-110

CAT: 0013-GTR19203594-04Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19203594-04Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-110 is a potent, ATP-competitive small-molecule inhibitor exhibiting high selectivity for PIM-3 kinase (IC50=47 nM) over PIM-1/2 (IC50=2.5 μM) . It demonstrates anti-proliferative activity in prostate cancer cell lines (IC50=0.6-0.9 μM), supporting its use in oncology research for studying PIM kinase signaling in vitro.
CAS Number
1395048-49-3
Product Name Alternative
M110, M-110, M 110, Pim3
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
98.30% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.48 mM) ; DMSO:50 mg/mL (112.12 mM)
Smiles
CC\C (=N/NC (=O) c1ccnc (NCCCN2CCOCC2) c1) c1ccc (Cl) cc1O
Molecular Formula
C22H28ClN5O3
Molecular Weight
445.94
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[(E)-1-(4-chloro-2-hydroxyphenyl)propylideneamino]-2-(3-morpholin-4-ylpropylamino)pyridine-4-carboxamide
CAS Number1395048-49-3
PubChem CID136246423
IUPAC NameN-[(E)-1-(4-chloro-2-hydroxyphenyl)propylideneamino]-2-(3-morpholin-4-ylpropylamino)pyridine-4-carboxamide
Molecular FormulaC22H28ClN5O3
Molecular Weight445.9
XLogP3.1
Topological Polar Surface Area99.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count31
Formal Charge0
Complexity587
SMILES
CC/C(=N\NC(=O)C1=CC(=NC=C1)NCCCN2CCOCC2)/C3=C(C=C(C=C3)Cl)O
InChI
InChI=1S/C22H28ClN5O3/c1-2-19(18-5-4-17(23)15-20(18)29)26-27-22(30)16-6-8-25-21(14-16)24-7-3-9-28-10-12-31-13-11-28/h4-6,8,14-15,29H,2-3,7,9-13H2,1H3,(H,24,25)(H,27,30)/b26-19+
InChIKey
FXXCNYVQIONABS-LGUFXXKBSA-N
Chemical Structure
2D Structure
2D structure of N-[(E)-1-(4-chloro-2-hydroxyphenyl)propylideneamino]-2-(3-morpholin-4-ylpropylamino)pyridine-4-carboxamide
CAS: 1395048-49-3
CID: 136246423
Formula: C22H28ClN5O3
MW: 445.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight445.9
XLogP33.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass445.1880675
Monoisotopic Mass445.1880675
Topological Polar Surface Area99.1 Ų
Heavy Atom Count31
Formal Charge0
Complexity587
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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