Products for Research Use Only
RegisterLogin

Nigericin

CAT: 0013-GTR19203880-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19203880-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nigericin is a polyether antibiotic with broad bioactivity, including antimicrobial, antimalarial, and anticancer properties. Its research applications involve studying ionophore-induced cell death mechanisms, such as pyroptosis and apoptosis via Caspase activation, in models like triple-negative breast cancer and primary effusion lymphoma, both in vitro and in vivo.
CAS Number
28380-24-7
Product Name Alternative
K+/H+ ionophore, Nigericin
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.50% (May vary between batches)
Solubility
Ethanol:45.91 mg/mL (63.33 mM) ; DMSO:5 mg/mL (6.9 mM)
Smiles
C[C@H]1[C@]2 (O[C@@] (C) (C1) [C@@]3 (O[C@@] (C) (CC3) [C@@]4 (O[C@] (C[C@@H]4C) ([C@]5 (O[C@] (CO) (O) [C@H] (C) C[C@@H]5C) [H]) [H]) [H]) [H]) O[C@H] (C[C@@H]6O[C@@] ([C@H] (C (O) =O) C) ([C@@H] (C) CC6) [H]) C[C@@H] (OC) [C@H]2C
Molecular Formula
C40H68O11
Molecular Weight
724.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Nigericin

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. It has a role as an antimicrobial agent, an antibacterial agent, a bacterial metabolite and a potassium ionophore.

CAS Number28380-24-7
PubChem CID34230
IUPAC Name(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid
Molecular FormulaC40H68O11
Molecular Weight725.0
XLogP5.5
Topological Polar Surface Area142
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Heavy Atom Count51
Formal Charge0
Complexity1230
SMILES
C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
InChI
InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1
InChIKey
DANUORFCFTYTSZ-SJSJOXFOSA-N
Chemical Structure
2D Structure
2D structure of Nigericin
CAS: 28380-24-7
CID: 34230
Formula: C40H68O11
MW: 725.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight725.0
XLogP35.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass724.47616298
Monoisotopic Mass724.47616298
Topological Polar Surface Area142 Ų
Heavy Atom Count51
Formal Charge0
Complexity1230
Isotope Atom Count0
Defined Atom Stereocenter Count19
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19180938Nigracin

Alternative Products

CatalogName
BA1112-10Nigericin
N015-50MGNigericin sodium

Popular Products