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Dirlotapide

CAT: 0013-GTR19203472-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203472-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dirlotapide (CP742033) is a selective intestinal MTP inhibitor that reduces body weight in diabetic dogs by dose-dependently decreasing food intake, potentially via enhanced peptide YY release. It is used in obesity research, with studies demonstrating its effects in both in vivo canine models and in vitro assays investigating lipid metabolism.
CAS Number
481658-94-0
Product Name Alternative
MTP, CP 742033, CP742033, CP-742033, Dirlotapide, Slentrol
Field of Research
Metabolism Research, Protein Biochemistry
Purity
98.47% (May vary between batches)
Solubility
DMSO:262.5 mg/mL (389.06 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CN (Cc1ccccc1) C (=O) [C@@H] (NC (=O) c1cc2cc (NC (=O) c3ccccc3-c3ccc (cc3) C (F) (F) F) ccc2n1C) c1ccccc1
Molecular Formula
C40H33F3N4O3
Molecular Weight
674.71
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Dirlotapide

Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human use.

CAS Number481658-94-0
PubChem CID9917862
IUPAC NameN-[(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide
Molecular FormulaC40H33F3N4O3
Molecular Weight674.7
XLogP7.7
Topological Polar Surface Area83.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count50
Formal Charge0
Complexity1150
SMILES
CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)N[C@@H](C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
InChI
InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1
InChIKey
TUOSYWCFRFNJBS-BHVANESWSA-N
Chemical Structure
2D Structure
2D structure of Dirlotapide
CAS: 481658-94-0
CID: 9917862
Formula: C40H33F3N4O3
MW: 674.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight674.7
XLogP37.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass674.25047541
Monoisotopic Mass674.25047541
Topological Polar Surface Area83.4 Ų
Heavy Atom Count50
Formal Charge0
Complexity1150
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5768916Dirlotapide

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