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EHT 1610

CAT: 0013-GTR19203383-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203383-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EHT 1610 is a highly potent and selective DYRK1A/B inhibitor with sub-nanomolar IC50 values. It demonstrates anti-leukemic activity in research settings by disrupting cell cycle progression and promoting apoptosis in vitro, supporting its investigation in oncology and cell signaling studies.
CAS Number
1425945-60-3
Product Name Alternative
DYRK2, DYRK1B, DYRK1A, DYRK3, CLK1, CLK2, Clk4, GSK-3α, GSK3α, GSK3β, GSK-3β, GSK3, EHT5372, EHT-5372, EHT 5372, EHT1610, EHT-1610, EHT 1610, p65, NFκB, NFkB, NF-kB, Tyrosinase
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.27% (May vary between batches)
Solubility
DMSO:4.5 mg/mL (11.74 mM)
Smiles
COC (=N) c1nc2ccc3ncnc (Nc4ccc (OC) cc4F) c3c2s1
Molecular Formula
C18H14FN5O2S
Molecular Weight
383.4
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Methyl 9-((2-fluoro-4-methoxyphenyl)amino)thiazolo[5,4-f]quinazoline-2-carbimidate
CAS Number1425945-60-3
PubChem CID71529602
IUPAC Namemethyl 9-(2-fluoro-4-methoxyanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate
Molecular FormulaC18H14FN5O2S
Molecular Weight383.4
XLogP4.2
Topological Polar Surface Area121
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity544
SMILES
COC1=CC(=C(C=C1)NC2=NC=NC3=C2C4=C(C=C3)N=C(S4)C(=N)OC)F
InChI
InChI=1S/C18H14FN5O2S/c1-25-9-3-4-11(10(19)7-9)23-17-14-12(21-8-22-17)5-6-13-15(14)27-18(24-13)16(20)26-2/h3-8,20H,1-2H3,(H,21,22,23)
InChIKey
RYBNARZBIXTFJS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Methyl 9-((2-fluoro-4-methoxyphenyl)amino)thiazolo[5,4-f]quinazoline-2-carbimidate
CAS: 1425945-60-3
CID: 71529602
Formula: C18H14FN5O2S
MW: 383.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.4
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass383.08522404
Monoisotopic Mass383.08522404
Topological Polar Surface Area121 Ų
Heavy Atom Count27
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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