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PF-06263276

CAT: 0013-GTR19203285-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203285-02Size:5 mg
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Description
PF-06263276 is a potent and selective pan-JAK inhibitor, demonstrating IC50 values of 2.2 nM (JAK1), 23.1 nM (JAK2), 59.9 nM (JAK3), and 29.7 nM (TYK2) . This small molecule is a valuable research tool for investigating JAK/STAT signaling in autoimmune and inflammatory disease models, both in cellular and preclinical studies.
CAS Number
1421502-62-6
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
CCc1cc (O) c (F) cc1-c1ccc2c (n[nH]c2c1) -c1nc2CCN (Cc2[nH]1) C (=O) c1cnc (cn1) N1CCCCC1
Molecular Formula
C31H31FN8O2
Molecular Weight
566.63
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PF-06263276

a pan-Janus kinase inhibitor; structure in first source

CAS Number1421502-62-6
PubChem CID135567296
IUPAC Name[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone
Molecular FormulaC31H31FN8O2
Molecular Weight566.6
XLogP4.1
Topological Polar Surface Area127
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count42
Formal Charge0
Complexity941
SMILES
CCC1=CC(=C(C=C1C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)CN(CC5)C(=O)C6=CN=C(C=N6)N7CCCCC7)F)O
InChI
InChI=1S/C31H31FN8O2/c1-2-18-13-27(41)22(32)14-21(18)19-6-7-20-24(12-19)37-38-29(20)30-35-23-8-11-40(17-26(23)36-30)31(42)25-15-34-28(16-33-25)39-9-4-3-5-10-39/h6-7,12-16,41H,2-5,8-11,17H2,1H3,(H,35,36)(H,37,38)
InChIKey
XDJGNPSZQSWJCV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PF-06263276
CAS: 1421502-62-6
CID: 135567296
Formula: C31H31FN8O2
MW: 566.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight566.6
XLogP34.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass566.25540042
Monoisotopic Mass566.25540042
Topological Polar Surface Area127 Ų
Heavy Atom Count42
Formal Charge0
Complexity941
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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