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R121919

CAT: 0013-GTR19203209-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19203209-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R121919 (NBI30775) is a potent small molecule antagonist of the corticotropin-releasing factor receptor 1 (CRF1), also exhibiting activity at the CRF2 receptor and CRF-binding proteins. Its antidepressant and anxiolytic properties make it a valuable research tool for investigating stress-related disorders in both in vitro binding assays and in vivo behavioral models.
CAS Number
195055-03-9
Product Name Alternative
R 121919, R-121919, R121919, NBI 30775, NBI30775, NBI-30775, CRF2, CRF1
Field of Research
Pharmacology & Drug Discovery
Purity
99.75% (May vary between batches)
Solubility
DMSO:5 mg/mL (13.14 mM) ; Ethanol:80 mg/mL (210.23 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM)
Smiles
CCCN (CCC) c1cc (C) nc2c (c (C) nn12) -c1cnc (cc1C) N (C) C
Molecular Formula
C22H32N6
Molecular Weight
380.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

R121919
CAS Number195055-03-9
PubChem CID9821250
IUPAC Name3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Molecular FormulaC22H32N6
Molecular Weight380.5
XLogP4.7
Topological Polar Surface Area49.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity480
SMILES
CCCN(CCC)C1=CC(=NC2=C(C(=NN12)C)C3=CN=C(C=C3C)N(C)C)C
InChI
InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
InChIKey
ANNRUWYFVIGKHA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of R121919
CAS: 195055-03-9
CID: 9821250
Formula: C22H32N6
MW: 380.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.5
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass380.26884505
Monoisotopic Mass380.26884505
Topological Polar Surface Area49.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5279-5.1R121919
HY-115645R121919 (hydrochloride)
HY-14127RR121919 (Standard)

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